Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC035
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-01 14:32
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient,madopar 4x1\2,Madopar hbs 2x1,Mirapexin1x1,Sermion2x1 DIFFICULITIES WITH ELEL

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 39 individuals with a value less than 0.71 were subsequently diagnosed with PD. That is, 92.86% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.71 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 31, 'TN': 25, 'TP': 11, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 6, 'TN': 8, 'TP': 36, 'FP': 22}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 35, 'TN': 29, 'TP': 7, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 19.956
timePerCircleCoV 0.132404
timePerCircleSlope -0.0348767
meanError 1.49354
tremorFreq 5.95703
tremorRelPower 31.2356
tremorGyroAmpMean 0.0145982
tremorGyroAmpSlope -0.00278841
tremorGyroAmpCoV 0.411231
tremorCoordAmpMean 0.0336681
tremorCoordAmpSlope -0.00104961
tremorCoordAmpCoV 0.333511
tremorAccAmpMean 0.029331
tremorAccAmpSlope -0.0015245
tremorAccAmpCoV 0.435625
tremorPcRelVar 0.648071
tremorPcX 0.858736
tremorPcY -0.512418

Circle Segment 1

Duration 26.0 s, Accuracy Estimate 1.776 (lower is better)

Circle Segment 2

Duration 21.12 s, Accuracy Estimate 1.214 (lower is better)

Circle Segment 3

Duration 22.04 s, Accuracy Estimate 1.103 (lower is better)

Circle Segment 4

Duration 18.72 s, Accuracy Estimate 1.338 (lower is better)

Circle Segment 5

Duration 18.6 s, Accuracy Estimate 1.211 (lower is better)

Circle Segment 6

Duration 19.92 s, Accuracy Estimate 1.292 (lower is better)

Circle Segment 7

Duration 18.48 s, Accuracy Estimate 1.566 (lower is better)

Circle Segment 8

Duration 20.24 s, Accuracy Estimate 1.483 (lower is better)

Circle Segment 9

Duration 17.28 s, Accuracy Estimate 1.47 (lower is better)

Circle Segment 10

Duration 17.16 s, Accuracy Estimate 2.482 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 42.3943
timePerSpiralCoV 0.24799
timePerSpiralSlope -0.0874107
meanError 1.67016
tremorFreq 6.15234
tremorRelPower 33.9239
tremorGyroAmpMean 0.0147655
tremorGyroAmpSlope -0.000839172
tremorGyroAmpCoV 0.397578
tremorCoordAmpMean 0.0413593
tremorCoordAmpSlope 0.00195319
tremorCoordAmpCoV 0.735912
tremorAccAmpMean 0.0729877
tremorAccAmpSlope 0.000214005
tremorAccAmpCoV 0.0886077
tremorPcRelVar 0.686327
tremorPcX 0.959902
tremorPcY 0.280335

Spiral Segment 1

Duration 61.84 s, Accuracy Estimate 1.465 (lower is better)

Spiral Segment 2

Duration 47.52 s, Accuracy Estimate 1.59 (lower is better)

Spiral Segment 3

Duration 37.12 s, Accuracy Estimate 1.571 (lower is better)

Spiral Segment 4

Duration 39.16 s, Accuracy Estimate 1.808 (lower is better)

Spiral Segment 5

Duration 37.12 s, Accuracy Estimate 1.618 (lower is better)

Spiral Segment 6

Duration 45.2 s, Accuracy Estimate 1.752 (lower is better)

Spiral Segment 7

Duration 28.8 s, Accuracy Estimate 1.887 (lower is better)

Elel

eDurationMean 0.450385
eDurationStd 0.139016
eDurationStdnorm 0.308661
eDurationMedian 0.41
eDurationQuartdelta 0.16
eDurationQuartdeltanorm 0.390244
eDurationKurt 2.85725
eDurationTrenddiff -0.105
eDurationTrendratio 0.771739
eWidthMean 5.424
eWidthStd 2.23004
eWidthStdnorm 0.411142
eWidthMedian 5.499
eWidthQuartdelta 1.8135
eWidthQuartdeltanorm 0.329787
eWidthKurt 14.3379
eWidthTrenddiff -0.351
eWidthTrendratio 0.9375
eHeightMean 9.468
eHeightStd 2.45207
eHeightStdnorm 0.258985
eHeightMedian 8.892
eHeightQuartdelta 3.159
eHeightQuartdeltanorm 0.355263
eHeightKurt 3.72848
eHeightTrenddiff -1.287
eHeightTrendratio 0.872093
eAspectMean 0.572571
eAspectStd 0.155369
eAspectStdnorm 0.271354
eAspectMedian 0.544444
eAspectQuartdelta 0.127035
eAspectQuartdeltanorm 0.233329
eAspectKurt 4.89656
eAspectTrenddiff 0.0315598
eAspectTrendratio 1.0599
eSlantMean -0.0607916
eSlantStd 0.214125
eSlantStdnorm -3.52227
eSlantMedian -0.0430108
eSlantQuartdelta 0.248725
eSlantQuartdeltanorm -5.78285
eSlantKurt 5.16573
eSlantTrenddiff -0.0491228
eRtopMean 0.694356
eRtopStd 0.146499
eRtopStdnorm 0.210986
eRtopMedian 0.704545
eRtopQuartdelta 0.200415
eRtopQuartdeltanorm 0.284461
eRtopKurt 2.98337
eRtopTrenddiff -0.0530303
eRbotMean 0.866098
eRbotStd 0.541835
eRbotStdnorm 0.625605
eRbotMedian 0.775
eRbotQuartdelta 0.330288
eRbotQuartdeltanorm 0.426177
eRbotKurt 20.1446
eRbotTrenddiff -0.00307018
eRrightMean 0.825982
eRrightStd 0.107772
eRrightStdnorm 0.130478
eRrightMedian 0.833333
eRrightQuartdelta 0.189909
eRrightQuartdeltanorm 0.227891
eRrightKurt 2.44704
eRrightTrenddiff -0.0694943
eRleftMean 0.445542
eRleftStd 0.117083
eRleftStdnorm 0.262788
eRleftMedian 0.431579
eRleftQuartdelta 0.179854
eRleftQuartdeltanorm 0.416734
eRleftKurt 2.41128
eRleftTrenddiff -0.0513232
lDurationMean 0.589342
lDurationStd 0.154697
lDurationStdnorm 0.262492
lDurationMedian 0.57
lDurationQuartdelta 0.165
lDurationQuartdeltanorm 0.289474
lDurationKurt 10.2352
lDurationTrenddiff -0.16
lDurationTrendratio 0.753846
lWidthMean 10.9364
lWidthStd 2.85189
lWidthStdnorm 0.26077
lWidthMedian 10.4715
lWidthQuartdelta 3.51
lWidthQuartdeltanorm 0.335196
lWidthKurt 3.22683
lWidthTrenddiff -0.468
lWidthTrendratio 0.955556
lHeightMean 24.9025
lHeightStd 5.0451
lHeightStdnorm 0.202594
lHeightMedian 24.7455
lHeightQuartdelta 7.254
lHeightQuartdeltanorm 0.293144
lHeightKurt 2.33526
lHeightTrenddiff 4.212
lHeightTrendratio 1.1791
lAspectMean 0.440587
lAspectStd 0.0812247
lAspectStdnorm 0.184356
lAspectMedian 0.415265
lAspectQuartdelta 0.108404
lAspectQuartdeltanorm 0.261047
lAspectKurt 3.63667
lAspectTrenddiff -0.087302
lAspectTrendratio 0.814887
lSlantMean 0.11497
lSlantStd 0.119718
lSlantStdnorm 1.0413
lSlantMedian 0.0986829
lSlantQuartdelta 0.163089
lSlantQuartdeltanorm 1.65266
lSlantKurt 3.27953
lSlantTrenddiff 0.0331492
lRtopMean 0.77541
lRtopStd 0.134734
lRtopStdnorm 0.173758
lRtopMedian 0.775135
lRtopQuartdelta 0.185065
lRtopQuartdeltanorm 0.238752
lRtopKurt 2.12079
lRtopTrenddiff 0.135185
lRbotMean 0.525865
lRbotStd 0.14722
lRbotStdnorm 0.279959
lRbotMedian 0.501899
lRbotQuartdelta 0.217978
lRbotQuartdeltanorm 0.434307
lRbotKurt 2.61662
lRbotTrenddiff -0.0280384
lRrightMean 0.876478
lRrightStd 0.0828705
lRrightStdnorm 0.0945494
lRrightMedian 0.895225
lRrightQuartdelta 0.107455
lRrightQuartdeltanorm 0.120031
lRrightKurt 3.37675
lRrightTrenddiff 0.05982
lRleftMean 0.304569
lRleftStd 0.117281
lRleftStdnorm 0.385073
lRleftMedian 0.305986
lRleftQuartdelta 0.171618
lRleftQuartdeltanorm 0.56087
lRleftKurt 2.03487
lRleftTrenddiff -0.0507421

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.949422
sumTouchScores 15.1908
meanMovementTime 1.139
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

FITTS Long Modified

meanTouchScore 0.930081
sumTouchScores 13.0211
meanMovementTime 1.33808
numTouches 14
undershootPercentage 0
overshootPercentage 14.2857

ZigZag

numZigzags 5
timePerZigzagMean 30.416
timePerZigzagCoV 0.202308
timePerZigzagSlope -0.122436
meanError 2.13505
tremorFreq 5.66406
tremorRelPower 27.7741
tremorGyroAmpMean 0.0217267
tremorGyroAmpSlope 0.00309423
tremorGyroAmpCoV 0.359648
tremorCoordAmpMean 0.0599687
tremorCoordAmpSlope 0.00373454
tremorCoordAmpCoV 0.312694
tremorAccAmpMean 0.0935783
tremorAccAmpSlope 0.00104802
tremorAccAmpCoV 0.123415
tremorPcRelVar 0.642885
tremorPcX -0.56618
tremorPcY -0.824282

ZigZag Segment 1

Duration 37.84 s, Accuracy Estimate 1.989 (lower is better)

ZigZag Segment 2

Duration 32.92 s, Accuracy Estimate 1.753 (lower is better)

ZigZag Segment 3

Duration 30.96 s, Accuracy Estimate 2.162 (lower is better)

ZigZag Segment 4

Duration 29.36 s, Accuracy Estimate 2.195 (lower is better)

ZigZag Segment 5

Duration 21.0 s, Accuracy Estimate 2.577 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 18.0933
timePerZigzagCoV 0.308528
timePerZigzagSlope -0.145405
zigzagHeightMean 77.5508
zigzagHeightCoV 0.0547153
zigzagHeightSlope 0.021898
meanError 0.0558889
tremorFreq 5.76172
tremorRelPower 31.5704
tremorGyroAmpMean 0.0419895
tremorGyroAmpSlope 0.00572653
tremorGyroAmpCoV 0.343617
tremorCoordAmpMean 0.103064
tremorCoordAmpSlope 0.0054818
tremorCoordAmpCoV 0.316425
tremorAccAmpMean 0.125871
tremorAccAmpSlope 0.00267047
tremorAccAmpCoV 0.182788
tremorPcRelVar 0.643831
tremorPcX 0.176213
tremorPcY 0.984352

ZigZag Offset Segment 1

Duration 24.96 s, Accuracy Estimate 0.11 (lower is better)

ZigZag Offset Segment 2

Duration 25.48 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 3

Duration 16.08 s, Accuracy Estimate 0.053 (lower is better)

ZigZag Offset Segment 4

Duration 14.2 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 5

Duration 14.08 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 6

Duration 13.76 s, Accuracy Estimate 0.057 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.67}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.71}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7719968575135849}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9250650261138671}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7259499135460237}